DeTOKI identifies and characterizes the dynamics of chromatin TAD-like domains in a single cell
Abstract Topologically associating domains (TAD) are a key structure of the 3D Eye serum mammalian genomes.However, the prevalence and dynamics of TAD-like domains in single cells remain elusive.Here we develop a new algorithm, named deTOKI, to decode TAD-like domains with single-cell Hi-C data.By non-negative matrix factorization, deTOKI seeks reg